Preparation and in vitro characterization of mucoadhesive hydroxypropyl guar microspheres containing amlodipine besylate for nasal administration
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Preparation and In Vitro Characterization of Mucoadhesive Hydroxypropyl Guar Microspheres Containing Amlodipine Besylate for Nasal Administration
Amlodipine besylate microspheres for intranasal administration were prepared with an aim to avoid first-pass metabolism, to achieve controlled blood level profiles and to improve therapeutic efficacy. Hydroxypropyl Guar, a biodegradable polymer, was used in the preparation of microspheres by employing water in oil emulsification solvent evaporation technique. The formulation variables were drug...
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Mucoadhesive chitosan microspheres of amlodipine besylate were prepared for nasal administration with the aim of avoiding the first pass effect. A series of batches of microspheres were prepared by simple emulsification crosslinking method to optimize parameters like external phase (mixture of heavy and light liquid paraffin in the ratio of 1:1), stirring rate (1200 rpm), dioctyl sodium sulfosu...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2011
ISSN: 0250-474X
DOI: 10.4103/0250-474x.100233